Aicar Pharmaceutical Aicar Acadesine CAS 2627-69-2

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Acadesine www.hormoneraw.com Skype:kevin_kafen WsApp:+8618027387093 Email:kevin@kafenbio.com Aicar Pharmaceutical Aicar Acadesine CAS 2627-69-2 Basic info. Product Name: AICAR Synonyms: ACADESINE;AICAR;AICA-RIBOSIDE;AMPK;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-BETA-RIBOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE-1-B-D-RIBOFURANOSIDE;5-AMINOIMIDAZOLE-4-CARBOXAMIDE 1-BETA-D-RIBOFURANOSIDE;Z-RIBOSIDE CAS: 2627-69-2 MF: C9H14N4O5 MW: 258.23 EINECS: 220-097-5 Usage: pharmaceutical intermediates.For the treatment of cardiovascular diseases. Product descrition: AICAR is a cell permeable activator of AMP-activated protein kinase (AMPK), a metabolic master regulator that is activated in times of reduced energy availability (high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulin-independent glucose uptake by skeletal muscle. Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro. Applications: AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase. AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress. AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways. Shipping & Delivery 1.Packages are generally dispatched within approximately 2 days after receipt of payment. 2.After the each shipping we will provide you with: 1) a link & tracking number to track your package online. 2) the few pictures with your order & details. 3.About the Custom clearance,we packed in disguise ways.In our experience,the appropriate and safe delivery,there won't be problems. 4.We confirm 99% clearance,100% resending. 5.Is it the best & safest shipping for all our repeat customers! Packing Details Discreet packing ways as your requirement, 100% go through. Storage Store in cool and dry area and keep away from direct sunlight.oC Shelf life 2 years, keep in formal storage condition. MOQ We accept any Qty you require, grams to kilograms. Samples Available, Contact now! Top reason why you choose us ? (1)Fast discreet delivery with great shipping success! (2)Pictures with your order & details! (3)We will provide you the tracking number! (4)Keep track of your goods untill the goods are sent in to your hands. (5)We confirm 99% clearance,100% resending. (6)High quality,100% pure products! (7)Delivery time approx.4-6 business days. (8)Best, Safe and Secure services. (9)Customer support 24/7. Order infos Payment Methods:West Union,Moeny Gram, Bitcoin and Bank Transfer. Delivery Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc. Shipment Time:Within 12 hours after confirmation of your payment Other Service:Safe shipment,high purity and best price for you.
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Mr. kevin smith

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