Anti - Emetic Pharmaceutical Raw Materials CAS 57808-66-9 Domperidone Motilium

Business Type
Manufacturer
Country
China

Product Detail

Product Description:
Place of Origin: China
Certification: ISO9001
Payment & Shipping Terms:
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Disguised
Delivery Time: 5-8 work days
Payment Terms: Western Union, MoneyGram, T/T, Bitcoin
Supply Ability: 1000kg a week
Domperidone CAS 57808-66-9 Brand:kafen
MW: 425.91 MSDS: Avaiable
MF:C22H24ClN5O2 Sample: Avaiable
Category: API Min order: 10grams
Quality standard: USP Place of Origin:China
Appearance Domperidone is a selective inhibitor of the peripheral D2DR. The antidopaminergic effects of Domperidone have been correlated to antiemetic and gastroprokinetic action.
Description
1). Domperidone (INN, USAN, BAN, JAN) (trade names Motilium, Motillium, Motinorm Costi, Nomit, Brulium Molax) is a medication developed by Janssen Pharmaceutica that acts as a peripherally selective antagonist of the dopamine D2 and D3 receptors. It is administered orally, rectally, or intravenously. Domperidone is given in order to relieve nausea and vomiting;
2). to increase the transit of food through the stomach (as a prokinetic agent through increase in gastrointestinal peristalsis); and to increase lactation (breast milk production) by release of prolactin. It is also used in the scientific study of the way dopamine (an important neurotransmitter and hormone) acts in the body.
3). Domperidone is available in the form of tablets, orally disintegrating tablets (based on Zydis technology),suspension and suppositories. Domperidone is a kind of potent peripheral dopamine receptor antagonist with anti-vomiting and gastro-kinetic effects.
4). It can affect the gastrointestinal motility to make the motility and tension of upper gastrointestinal tract return to normal and promote gastric emptying, enhancing the antral and duodenal motility, and coordinating the pyloric contraction. It can be used for the treatment of dyspepsia, and the nausea and vomiting induced by functional, organic, infection, dietary, radiation therapy or drug therapy.
5). Because it almost has no inhibitory effect on dopamine receptor, there are no psychiatric and neurological side effects. And it can be used for treating the nausea caused by treating the Parkinson's disease through taking dopamine agonists. It can be used as anticholinergic antispasmodics


Usages:
The uses or indications of domperidone vary between nations. For instance, in Italy it is used in the treatment of gastroesophageal reflux disease and in Canada, the drug is indicated in upper gastrointestinal motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents. A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent.

Application:
1). Domperidone is a kind of phenyl imidazole compounds with a strong role in promoting gastric motility and antiemetic effect. It can strengthen the tension of the sphincter of the lower part of the esophagus, preventing the stomach - esophageal reflux, enhancing the gastric motility, promoting the gastric emptying, coordinating the stomach and duodenal motility, suppressing nausea, vomiting, and effectively preventing the bile reflux without affecting the secretion of gastric juice.
2). This product is a kind of peripheral dopamine receptor antagonists which can directly block the gastrointestinal dopamine receptors and exhibit the stimulating effect of gastric motility. It can enhance the esophageal peristalsis and the tension of esophageal sphincter. Because of its poor penetration through the blood brain barrier, it has almost no antagonism against the dopamine receptor of the brain, and therefore can excluding the side effects of the spirit and the central nervous system.
3). A novel peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic. Domperidone(Motilium) is a dopamine blocker and an antidopaminergic reagent. For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.


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