Skin Natural Pharmaceutical White Raw Materials Betamethasone Acetate
Synonyms: 9ALPHA-FLUORO-16BETA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-ACETATE;9a-fluoro-16b-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-acetate;1,4-PREGNADIEN-9-ALPHA-FLUORO-16-BETA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE;BETAMETHASONE 21-ACETATE;BETAMETHASONE ACETATE;9-fluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-acetate;Betamethasone acetate BP/USP/EP;BETAMETHASONE ACETATE EPB(CRM STANDARD)
Chemical Properties White Solid
Usage amino acid, nutrient
Usage Betamethasone acetate (BA)
Betamethasone, dexamethasone of isomers, the role and purpose with dexamethasone acetate, the sodium and water retention effect and dose than the latter is small. Glucose metabolism and anti-inflammatory effect than hydrocortisone strong as hydrocortisone 15 times, but the effect of sodium retention hydrocortisone hundred times more, in primary adrenal hypofunction in with glucocorticoid steroid replacement therapy used together. Also suitable for low renin and low aldosterone syndrome, autonomic neuropathy induced orthostatic hypotension. Because of the goods taken orally is prone to cause edema, more topically applying topical treatment for seborrheic eczema, contact dermatitis, anal, genital itching embolism. Mainly used for allergic and autoimmune inflammatory diseases. It is used for activities rheumatism, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, but also for the comprehensive treatment of certain infections.
Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties. Unlike other drugs with these effects, betamethasone does not cause water retention. It is applied as a topical cream, ointment, foam, lotion or gel to treat itching. Betamethasone sodium phosphate is sometimes prescribed as an intramuscular injection for itching from various ailments, including allergic reactions to poison ivy and similar plants.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.Betamethasone Sodium Phosphate and Betamethasone Acetate Injectable Suspension, USP is a sterile aqueous suspension containing betamethasone 3 mg per milliliter as betamethasone sodium phosphate, and betamethasone acetate 3 mg per milliliter. Inactive ingredients per mL: dibasic sodium phosphate 7.1 mg; monobasic sodium phosphate 3.4 mg; edetate disodium 0.1 mg; and benzalkonium chloride 0.2 mg as a preservative. The pH is adjusted to between 6.8 and 7.2.
The formula for betamethasone sodium phosphate is C22H28FNa2O8P and it has a molecular weight of 516.40. Chemically, it is 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-(disodium phosphate).
The formula for betamethasone acetate is C24H31FO6 and it has a molecular weight of 434.50. Chemically, it is 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-acetate.
Betamethasone sodium phosphate is a white to practically white, odorless powder, and is hygroscopic. It is freely soluble in water and in methanol, but is practically insoluble in acetone and in chloroform.
Betamethasone acetate is a white to creamy white, odorless powder that sinters and resolidifies at about 165C, and remelts at about 200C-220C with decomposition. It is practically insoluble in water, but freely soluble in acetone, and is soluble in alcohol and in chloroform.
Allergic to the goods and other steroid.The following diseases generally are not special circumstances should be weighed against the use, but should pay attention to disease progression may be: a serious mental illness (past or present), and epilepsy, active peptic ulcer disease, recent gastrointestinal anastomosis, fracture, wound healing period , corneal ulcers, adrenal cortex hyperactivity disorder, hypertension, diabetes, pregnant women, antibiotics can not control the infection, such as chicken pox, measles, fungal infections, heavier osteoporosis.
1.It is stronger than cortisol about methoxyflavone sugar metabolism and anti-inflammatory , amost 15 times stronger than cortisol.
2.For hydrocortisone sodium retention role,it is more than one hundred time stronger than cortisol.
3.In the primary adrenal cortical impairment of disease,it can be used for replacement therapy together with sugar corticosteroids.
4.It is also used for low renin and low aldosterone syndrome and plant nerve lesions orthostatic hypotension caused by etc.
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