Recombinant Human Mucin-1 / MUC-1 Protein (Fc Tag)

Business Type
Manufacturer
Country
China

Quick Details

Brand Name: Elabscience
Model Number: Catalog number:PKSH030274
Place of Origin: USA
MOQ: 1
Certificate: ISO9001:2008

Product Detail

Catalog number: PKSH030274 Synonyms:RP11-263K19.2, CD227, EMA, H23AG, KL-6, MAM6, PEM, PEMT, PUM Size: 50μg Qty: 1 Price: Inquire Species: Human Expression host: Human Cell Lead Time: 7~10 days Overview Synonyms: RP11-263K19.2, CD227, EMA, H23AG, KL-6, MAM6, PEM, PEMT, PUM Source Species: Human Overview Synonyms:RP11-263K19.2, CD227, EMA, H23AG, KL-6, MAM6, PEM, PEMT, PUM Source Species: Human Properties Form: Lyophilized from sterile PBS, pH 7.4 Purity: > 90 % as determined by SDS-PAGE Stability: Samples are stable for up to twelve months from date of receipt at -70? Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method Protein construction:A DNA sequence encoding the human MUC1 isoform 2 (NP_001018016.1) extracellular domain (Met 1-Gly 167) was fused with the Fc region of human IgG1 at the C-terminus. Predicted N Terminal: Ser 33 Molecular mass: The recombinant human MUC1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 376 amino acids after removal the signal peptide and has a predicted molecular mass of 42 kDa. As a result of glycosylation, rh MUC1/Fc monomer migrates as an approximately 55-60 kDa band in SDS-PAGE under reducing conditions. Expression host: Human Cell Background: Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. MUC-1/CC1/CD227 Exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, internalized and recycled to the cell membrane. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit has cell adhesive properties. MUC-1/CC1/CD227 Can act both as an adhesion and an anti-adhesion protein. This protein May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. MUC-1/CC1/CD227 participated in modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, MUC-1/CC1/CD227 influences directly or indirectly the Ras/MAPK pathway. MUC-1/CC1/CD227 Promotes tumor progression and regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

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About our Company

Business Type
Manufacturer
Established
2011
Employess
201 - 300 People
Annual Revenue
US$5 Million - US$10 Million
Main Markets
North America, Eastern Europe, East Asia, Africa, South America, Southern Europe, South Asia, Oceania, Central America, Western Europe, Middle East
Products
Laboratory Reagents

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Laboratory Reagents in China

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Elabscience Biotechnology,Inc.

Ms. Emily Yang

14780 Memorial Drive, Suite 216.

Houston Texas 77079 China

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